The PRISM modeling project focuses on modeling to inform integrated advice for pandemic response. PRISM will work in collaboration with the pandemic modeling work package team in the ZonMw-funded UNITY project to develop and deploy models that simulate and compare pandemic policy options. The goal is to establish a generic individual-based model (IBM) framework for human-to-human transmitted respiratory infections in the Netherlands.

The framework will be able to simulate both pharmaceutical and nonpharmaceutical interventions, potentially tailored to specific geographic regions, with consideration of the effectiveness and uptake across different regions and demographic groups. In addition, the model will be designed to facilitate rapid adaptations to expert and stakeholder inputs about key uncertainties, such as disease biology and intervention uptake and effects.