On 17 October 2024, the Erasmus MC / TU Delft MOtion Biomechanics & Imaging (MOBI) Lab will open its doors at Erasmus MC in Rotterdam. This innovative research centre is the culmination of a unique collaboration between Erasmus MC and TU Delft, and is a significant step in our joint mission: to accelerate the translation of technological innovations into clinical practice, with the aim of creating direct benefits for society.

 

Program

Research symposium on Joint Biomechanics in OsteoArthritis (chair: Jaap Harlaar)

13:00 Welcome
13:10 Keynote lecture by Bill Taylor (ETH Zurich) “the power of fluoroscopy for joint biomechanics”
13:50 Keynote lecture by Gerjo van Osch (Erasmus MC, Rotterdam) “Joint LoaD in knee osteoartritis, a multiscale approach”
14:30 Coffee break in the Foyer

Opening symposium of the MOBI-lab (Chair : Erin Macri)

15:00

Alfred Schouten, Denise Eygendaal and Aad van der Lugt: A Collaborative Welcome
heads of the dept.of Biomechanical Engineering (TUDelft) ; dept Orthopedics & Sports medicine & dept of Radiology and Nuclear Medicine (ErasmusMC)

15:10 Sita Bierma-Zeinstra: Osteoarthritis: The Silent Epidemic
Professor of Osteoarthritis and related joint disorders, ErasmusMC dept. General Practise & Orthopedics & Sports medicine
15:20 Edwin Oei: Advances in Imaging of Osteoarthritis, from Structure to Function
Professor of musculoskelatal imaging, dept Radioloy & Nuclear Medicine
15:30 Ajay Seth: Personalisation of Biomechanical Models
professor of computational movement biomechanics , TUdelft, dept. Biomechanical Engineering
15:40 Jaap Harlaar: The MOBI lab and how it came about
Professor of clinical biomechanics TUDelft (dept. Biomechanical Engineering) & ErasmusMC (dept Orthopedics & Sports medicine)
15:50 Stefan Sleijfer: Convergence of Health & Tech: Where we are and where we’ll go
Chair Convergence Executive Board
16:00 Closure of the symposium, change location to the Plaza (“binnentuin” between Ne and Nf)*
16:15 Official opening of the MOBI-lab by Fred van Keulen* and Stefan Sleijfer# * Dean of the faculty of Mechanical Engineering, TUDelft # Chair and Dean of the Board of Directors Erasmus Medical Center Rotterdam
16:20 Drinks & snacks in the Plaza
16:20 And on: opportunity to visit the lab in groups of 8 (registration @ Plaza)
17:30 Closing

 

Speakers:

Keynote lecture by Bill Taylor: The Power of Fluoroscopy for Joint Biomechanics

  • Bill Taylor is  Professor of Movement Biomechanics within the Department of Health Sciences and Technology at ETH Zürich since  2012. He is Mechanical Engineer, and specilialized in Biomedical Engineering . In 2001 he joined the Julius Wolff Institute, Charité – Universitätsmedizin Berlin .

    Bill has led many impressive research projects , concerning  joint biomechanics. Let me just name the CAMS-Knee project , that yielded an open source database of knee joint biomechanics, including in vivo knee load measurements along with fluoroscopy. His latest achievement is a great piece of engineering for in vivo dual fluoroscopy measurements, that he will demonstrate. 

Keynote lecture by Gerjo van Osch: Joint LoaD in Osteoarthritis, a Multiscale Approach

  • Gerjo van Osch, is professor of mechanobiology at the dept or Orthopeadics and sportsmedicine, and also as Medical Delta Professor , affiliated to TUDelft dept Biomechnical engineering. She is also ice dean of Research at the ErasmusMC

    Gerjo was trained in medical biology and specialized in mechanobiology of cells, with a special interest in cellular mechanisms involved in cartilage (re)generation and degeneration.

    Gerjo leads a very large national consortium, called LoaD, being the topic of her talk

 Osteoartritis: the silent epidemic | Sita Bierma-Zeinstra

In this presentation I will focus on the current state of the art in clinical OA research, including why early treatment is needed, and certain treatments should be subgroup specific.

 

  • Sita Bierma-Zeinstra is professor of Osteoarthritis and Related Disorders at the Department of General Practice and the Department of Orthopedics and Sports Medicine. She is a renown clinical researcher with the emphasis on prevention and early detection and treatment of OA, with subgrouping for targeted treatment where needed. She leads important initiatives in these areas like the OA Trial Bank, the research centre of excellence OA Prevention and Early Treatment (OA PEARL), and the convergence flagship Healthy Joints. As Medical Delta professor she also has an appointment at the TU Delft dept. of Biomechnical Engineering.

 

 Advances in Imaging of Osteoarthritis, from structure to function  | Edwin Oei

In this presentation I will highlight activities of the Advanced Musculoskeletal Imaging Research Erasmus MC (ADMIRE) group in developing, validating and implementing imaging biomarkers in clinical trials on osteoarthritis and how this field is moving towards the future. I will address the utility of traditional “static” MRI, followed by more novel quantitative MRI techniques to assess altered joint tissue composition and blood perfusion in osteoarthritis. Next, I will highlight the most novel imaging technique, hybrid PET-MRI, which allows visualization of metabolic joint processes. Finally, I will emphasize how, moving forward, information on joint load and biomechanics from the MOBI-lab will complement and advance imaging of osteoarthritis.

 

  • Edwin Oei is Professor of Musculoskeletal Imaging and Chief of Musculoskeletal Radiology at Erasmus MC. He leads the Advanced Musculoskeletal Imaging Research Erasmus MC (ADMIRE) group which focuses on development, validation and implementation of novel quantitative imaging biomarkers for major musculoskeletal diseases, particularly osteoarthritis, using various radiological and hybrid imaging modalities

 

 Personalisation of Biomechanical models | Ajay Seth

  • Ajay Seth is  Assistant Professor who leads the Computational Biomechanics Lab in the department of Biomechanical Engineering at TU Delft. When based in Stanford University, Dr. Seth was the architect who created OpenSim, a world renowned open source software system for performing biomechanical modeling, simulation and analysis.

 

The MOBI lab, how and why it came about | Jaap Harlaar

In this presentation I will focus on the importance of proper assessment of the pathomechanics of cartilage load in vivo, in order (a) to better understand the etiology of cartilage degeneration and (b) to arrive at personalized treatment, based on the recognition of pathomechanical subtypes of OsteaArthritis. I will stress the importance of high level research on movement biomechanics ánd tissue biomechanics to be applied in a clinical context of high level clinical research, to make this happen… I will also explain the five year history of conceptualization of the MOBI, including the barriers we had to take, together with upcoming projects and plans.

 

  • Jaap Harlaar is Professor of Clinical Biomechanics, appointed both at the dept. of Biomechnical Engineering and at the dept. or Orthopedics. After some decades at VU Amsterdam, with a main focus on gait analysis in children with Cerebral palsy, he jointed TUDelft and ErasmusMC orthopeadics to put pathomechanics of cartilage load into the equation of the research on osteoarthritis.