The digital transformation is irreversible, rapid and has changed much of the past decade. Digitalisation offers great opportunities as well as big challenges, and there is currently a global race for leadership in this field. Focusing on a knowledge cluster that can resolve socio-economic, security and sustainability problems with the help of AI is essential for our country. The mission of the knowledge cluster is to be a continuously strong and globally prominent knowledge cluster with great social impact, where via convergence, real solutions and applications by AI are developed for the complex and current challenges facing society. If we do this together, and based on different disciplines, we can take huge strides. Together, we are preparing for the research agendas that are under development and the resulting financing opportunities so that steps can be made from AI, data & digitalisation and to contribute to the big regional, national and international social challenges.