About this position
Every person is unique and so understanding how to optimally treat or prevent disease requires personalized cell culture models in order to disentangle genetic and environmental factors that determine an individual’s disease risk and treatment response. The arrival of induced pluripotent stem cells (iPSCs) has made this exciting new approach possible. However, iPSC studies are usually done on small numbers of donors. In order to apply iPSC cultures in the clinic, we need to examine large numbers of individuals in an efficient way. In the collaborative and multidisciplinary “Convergence in a dish” project that combines expertise from TU-Delft, Erasmus MC and Erasmus University, we aim to build a large-scale individualized cell culture platform (iCELL) where iPSCs from many individuals are co-cultured under controlled environmental conditions. Your role will be to combine advanced iPS technologies (“village on a dish”) and single cell readout parameters to unravel the influence of genetics in cellular pathways involved in disease progression. The candidate will work together with experts in stem cell differentiation, iPS culturing and bioinformatics from the department of Orthopaedics and Sports Medicine, and Molecular Genetics, with the support of the iPS core facility at the Erasmus MC.
We seek a PhD candidate with a strong affinity for research in the field of molecular biology, cell biology, bioinformatics and genetics. We are looking for a creative candidate with a and genuine interest in fundamental research, who is keen to work in an international and interdisciplinary team. Applicants must:
• hold a Master’s degree, or approach its completion, in biology, biotechnology, molecular biology, bioinformatics or a closely related discipline;
• have research experience in cell culture, cellular/molecular technologies, and/or bioinformatics;
• have an English level to ensure that the candidate is able to communicate and interact well, participate in English-taught Doctoral Education courses, and write scientific articles and a final thesis;
• thrive in an international, multidisciplinary and highly collaborative environment.